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Both the ZDX and RZ have child safety locks to prevent children from opening the rear doors. The ZDX has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The RZ’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
The ZDX’s standard pretensioning seatbelts also sense rear collisions and remove slack from the seatbelts to help protect the occupants from whiplash and other injuries. The RZ doesn’t offer a whiplash protection system.
Both the ZDX and the RZ have standard driver and passenger frontal airbags, front side-impact airbags, driver and front passenger knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning and available around view monitors.
The Acura ZDX weighs 802 to 1775 pounds more than the Lexus RZ. The NHTSA advises that heavier vehicles are much safer in collisions than their significantly lighter counterparts.